Trifexis - Poison Or An Effective Drug?

Want to use Trifexis to help your dog get rid of fleas? Or your dog is infested so you're in a hurry to find some miraculous cure, and you know the Trifexis may help? But wait a moment, you have to learn more about Trifexis, because it may harm your dog.


What is Trifexis?

Trifexis is a sort of chewable tablet, a veterinary medicine that contains two active substances, spinosad and milbemycin oxime.

It is used for killing your dog's fleas. As well as flea infestations it also treats and controls heartworm disease and intestinal parasites (adult hookworm, roundworm and whipworm infections).

Your dog will like this tablet because it is beef-flavored. It feels like you are tricking your dog to eat such a tablet but you definitely have good intentions.
Pay attention, the medicine is only approved for use on dogs and puppies 8 weeks of age or older and 5 pounds of body weight or higher.

trifexis tablets

Why use Trifexis?

Watch this video to learn more:

You know how horrible fleas are! Fleas have an incredible jumping ability. They can easily leap onto your dog from ground level and begin feeding on your dog's blood in seconds.

After their first blood meal, they start laying eggs, which can quickly lead to an infestation. What's more, little specks of “flea dirt” on your dog’s skin is actually undigested blood excreted by fleas. You’ve likely got an infestation too.

Once bitten by fleas, your dog will be in severe discomfort, symptoms include scratching, chewing, biting and restlessness. Severe flea infestations can cause anemia, especially in puppies or debilitated adult dogs and ingested fleas can also transmit tapeworm infections to dogs.

Flea infestations can also put you and your family at risk for health issues, which is due to the higher possibility of experiencing bites from newly emerging fleas.


You must hope that your lovely dog, and your life is not under the influence of insects. Flea control is a vital part of caring for your dog.

Spinosad, one of the active ingredients of Trifexis, starts killing fleas within 30 minutes and was proved 100% effective within four hours. Besides, Trifexis protects your dog from fleas because it lasts for a full month, kills fleas before they can lay eggs, and it can't be rubbed, washed or shaken off.

killing fleas using Spinosad

Precautions you should know

Trifexis is not available for people. If the medicine is accidentally ingested, you should immediately seek medical advice or go to the hospital.

You should wash your hands after handling the product, and you should put it in the safe place where children can't reach it.

Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.

You should test your dog for existing heartworm infection before feeding them Trifexis.

The shocking side effects of Trifexis you should never neglect!

Like all medicine, Trifexis is not perfect. This chewable tablet may cause severe adverse reactions. For example, “vomiting during the 48 hours after treatment is common.”

It is mild and short lived without requiring treatment in most cases. Other common side effects include lethargy (sluggishness), decreased appetite, diarrhea, pruritus (itching), dermatitis (inflammation of the skin) and reddening of the skin and ear, etc. - European Medicines Agency

sick dog

The side effects of Trifexis may be far worse than the leaflet advertised. Because some reports showed issues below: failure of the product to rid hookworms, blindness immediately post, seizures, “fly biting” an air snapping behavior typical in epileptic dogs, lethargy, weakness in rear limbs; paralysis, as well as death.

The most striking in all these reports is that some of them came on after the first dose, many happened after months of use or a year.

The first death case was reported by Atlanta television station WSB in November 2013. Dog owners in Atlanta (and elsewhere) claiming the trifexis had caused their pets' death. In 2014, the complaints related to Trifexis had gone up by nearly 40 percent since the first report.

On the other hand, the investigation was going on.

The company of Trifexis, Elanco responsed, “the drug is innocent, and there is no direct proof to show a correlation between the two.”

Veterinarian Doc Cleland said, ”If animals receiving Trifexis causes more deaths or problems than animals without, then there is a positive correlation between Trifexis and death." The fact is there is still not enough proof.

The shocking side effects of Trifexis

What can we expect?

Reports may not be an indication of causes because it's very hard to exclude other factors such as underlying disease, using other drugs at the same time, or other non-drug related causes. Therefore, it may never find an accurate answer to explain this issue.

As the most popular flea and heartworm pill, more than 50 million doses dispensed, and most of the dogs on Trifexis are fine.

While watching your dog's death is heartbreaking. One of the dog owners had described it as "it’s like a piece of your heart is being torn out.” It’s true.

To decrease the risk of using Trifexis, you may need to use medicine more cautiously. Once you find something wrong with your dog after feeding him medicine, you should immediately take him to a veterinarian. Keeping an eye on the response of dogs may save their lives.

Finally, let's hope better medicine products can be found to help dogs live a healthier life and can accompany us for longer.


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